While our High Ground Immune works through the endocannabinoid system to support immune system response, Our CB2™ line works through direct activation of our body’s CB2 receptors, which has the following possible benefits:
• Reduces stress and anxiety (i ii). (factors that influence on how well the immune system responds to challenges) (iii)(iv)
• Immune modulation(v)(vi) and anti-inflammatory benefits(vii)(viii) (can help dampen the cytokine storm and resulting damage leading to acute respiratory distress syndrome (ARDS—the primary cause of mortality with COVID-19)
• Reduce lung fibrosis(ix) (which is appears to be consequence of COVID-19x and could result in long lasting or permanent lung damage in survivors)
i Anxious behavior induces elevated hippocampal CB2 receptor gene expression. Neuroscience. 2017 Jun 3;352:273-284.
ii Regulatory role of CB2 in stress-induced neuroinflammation in mice. Br J Pharmacol. 2014 Jun;171(11):2814-26.
iii Immune system. Relationship to anxiety disorders. Psychiatr Clin North Am. 1988 Jun;11(2):349-60.
iv Stress, Anxiety, and Immunomodulation: A Pharmacological Analysis. Vitam Horm. 2017;103:1-25.
v Emerging role of CB2 in immune regulation: therapeutic prospects for neuroinflammation. Expert Rev Mol Med. 2009 Jan 20;11:e3.
vi CB2: potential role in immunomodulation and neuroinflammation. J Neuroimmune Pharmacol. 2013 Jun;8(3):608-20.
vii Role of CB2 in mediating interleukin-1β-induced inflammation. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):1026-1035. Epub 2019 Mar 18.
viii CB2 and its role as a regulator of inflammation. Cell Mol Life Sci. 2016 Dec;73(23):4449-4470. Epub 2016 Jul 11.
ix CB2 agonist prevents nicotine induced lung fibrosis. Exp Lung Res. 2018 Sep;44(7):344-351
x Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet. Epub 2020 Feb 24.